Cholesterol nanoarchaeosomes for alendronate targeted delivery as an anti-endothelial dysfunction agent

• Horacio Emanuel Jerez,
• Yamila Roxana Simioni,
• Kajal Ghosal,
• Maria Jose Morilla and
• Eder Lilia Romero

Beilstein J. Nanotechnol. 2024, 15, 517–534, doi:10.3762/bjnano.15.46

• embryogenesis [53]. EndMT is observed under inflammatory conditions similar to the environment generated during sepsis or pathological processes such as renal, cardiac and pulmonary fibrosis, and cancer [54][55][56][57]. In the mild inflation model, LPS induced in HUVECs morphological changes compatible with

• ratio (Figure 12). Dexamethasone partly reduced the morphological changes induced on HUVECs but did not affect the IL-6/IL-8 production. In the pronounced inflammation model, the morphological changes experienced by HUVECs were not reversed by any treatment (data not shown). Discussion The in vitro anti

• of this research suggest that the endocytosis of one specific formulation, nanoARC-Chol(ALN), by irritated HUVECs in the mild inflammation model, was beneficial. The same as dexamethasone, nanoARC-Chol(ALN) was partly capable of reducing the morphological changes caused by LPS, potentially caused by

Heat-induced morphological changes in silver nanowires deposited on a patterned silicon substrate

• Elyad Damerchi,
• Sven Oras,
• Edgars Butanovs,
• Allar Liivlaid,
• Mikk Antsov,
• Boris Polyakov,
• Annamarija Trausa,
• Veronika Zadin,
• Andreas Kyritsakis,
• Loïc Vidal,
• Karine Mougin,
• Siim Pikker and
• Sergei Vlassov

Beilstein J. Nanotechnol. 2024, 15, 435–446, doi:10.3762/bjnano.15.39

• process, fragmentation in either adhered or suspended parts can dominate. Experiments were supported by finite element method and molecular dynamics simulations. Keywords: diffusion; finite element method; heat treatment; molecular dynamics simulations; morphological changes; scanning electron microscopy

• . However, during prolonged heat treatment (lasting minutes or more), surface atom diffusion can lead to morphological changes in NWs even at temperatures several hundred degrees below the melting point of the material [26][27]. Sintering of Ag and Au NWs at intersections can occur at temperatures as low as

• pentagonal structure is preserved even for small fragments of NWs that were split as a result of heat treatment as shown in Figure 7 (note that the fragments are kept in place due to contact with the thin carbon membrane of the TEM grid). These findings suggests that heat-induced morphological changes in Ag

Graphene removal by water-assisted focused electron-beam-induced etching – unveiling the dose and dwell time impact on the etch profile and topographical changes in SiO₂ substrates

• Aleksandra Szkudlarek,
• Jan M. Michalik,
• Inés Serrano-Esparza,
• Zdeněk Nováček,
• Veronika Novotná,
• Piotr Ozga,
• Czesław Kapusta and
• José María De Teresa

Beilstein J. Nanotechnol. 2024, 15, 190–198, doi:10.3762/bjnano.15.18

• nanopatterning, we have found significant morphological changes induced in the SiO2 substrate even at low electron dose values (<8 nC/μm2). We demonstrate that graphene etching and topographical changes in SiO2 substrates can be controlled via electron beam parameters such as dwell time and dose. Keywords

• from graphene etching, the morphological changes in the SiO2 surface are visible in AFM and CPEM results for lines that were extended beyond the flake area (see Figure 1D). The experiments confirm that water-assisted FEBIE is a fast and direct technique to selectively remove graphene. The process must

• substrate with the same dwell time values (1, 10, and 100 μs) and the highest dose D5. The profiles extracted from the AFM data are shown in Figure 4 and confirm the morphological changes introduced into the SiO2 substrate. In this case, the middle protrusion is not observed. Discussion In general, the

Curcumin-loaded nanostructured systems for treatment of leishmaniasis: a review

• Douglas Dourado,
• Thayse Silva Medeiros,
• Éverton do Nascimento Alencar,
• Edijane Matos Sales and
• Fábio Rocha Formiga

Beilstein J. Nanotechnol. 2024, 15, 37–50, doi:10.3762/bjnano.15.4

• when treated by both nanoandi and nanocopa. Moreover, there was a decrease in lesion size and parasite load from the liver and spleen of mice treated with NE. In ultrastructural analysis performed by scanning electron microscopy, it was possible to observe morphological changes, oval aspect, and

Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials

• Celia Martín-Morales,
• Jorge Fernández-Méndez,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43

• silica matrix, yeast cells display a completely different morphology from that in common suspension cultures. The observed pseudohyphal growth corresponds to morphological changes that are usually correlated to stress for growing yeast cells [16]. Thus, the pseudohyphal growth could be likely caused by

In search of cytotoxic selectivity on cancer cells with biogenically synthesized Ag/AgCl nanoparticles

• Mitzi J. Ramírez-Hernández,
• Mario Valera-Zaragoza,
• Omar Viñas-Bravo,
• Ariana A. Huerta-Heredia,
• Miguel A. Peña-Rico,
• Erick A. Juarez-Arellano,
• David Paniagua-Vega,
• Eduardo Ramírez-Vargas and
• Saúl Sánchez-Valdes

Beilstein J. Nanotechnol. 2022, 13, 1505–1519, doi:10.3762/bjnano.13.124

• ] these color changes were also observed during the formation of AgNPs from the Stevia rebaudiana extract. This behavior was attributed to the gradual formation of Ag nanoparticles, and the morphological changes that occur during biosynthesis. It is important to note that temperature has a considerable

• (Figure 9) clearly shows that the morphological changes depend on the synthesis temperature and dosage of Ag/AgCl nanoparticles. The data show that the formation of apoptotic bodies (arrows) and the growth of cellular regions (black circles) are integral and characteristic of apoptosis. At high

• cells and MCF-7 cells with Ag/AgCl nanoparticles after 24 hours of exposure. The MCF-7 cell line shows increased cell area or morphological changes (black circles) and formation of apoptotic bodies (arrows). At high concentrations, a large number of cells in a necrotic state were detected (black box

A non-enzymatic electrochemical hydrogen peroxide sensor based on copper oxide nanostructures

• Irena Mihailova,
• Vjaceslavs Gerbreders,
• Marina Krasovska,
• Eriks Sledevskis,
• Valdis Mizers,
• Andrejs Bulanovs and
• Andrejs Ogurcovs

Beilstein J. Nanotechnol. 2022, 13, 424–436, doi:10.3762/bjnano.13.35

• storage, no significant morphological changes were observed, which proves the stability of the samples. These results show that the nanostructured CuO coating has long-term stability and resistance to environmental influences, which is another advantage compared to enzyme sensors. Conclusion This article

Theranostic potential of self-luminescent branched polyethyleneimine-coated superparamagnetic iron oxide nanoparticles

• Rouhollah Khodadust,
• Ozlem Unal and
• Havva Yagci Acar

Beilstein J. Nanotechnol. 2022, 13, 82–95, doi:10.3762/bjnano.13.6

• agreement with the spectroscopic data (Figure 2b). Cells treated with free bPEI show a very weak optical signal in the cytoplasm, as expected (Figure 4c1–c3). In addition, significant morphological changes were observed in these cells due to the cytotoxic effect of bPEI on the cytoplasmic membrane and the

Polarity in cuticular ridge development and insect attachment on leaf surfaces of Schismatoglottis calyptrata (Araceae)

• Venkata A. Surapaneni,
• Tobias Aust,
• Thomas Speck and
• Marc Thielen

Beilstein J. Nanotechnol. 2021, 12, 1326–1338, doi:10.3762/bjnano.12.98

• of adaxial leaf surfaces at various ontogenetic stages to study the morphological changes occurring on the leaf surfaces. We characterized the replica surfaces by using confocal laser scanning microscopy and commercial surface analysis software. The development of cuticular ridges is polar and the

• morphological changes and structural integrity of plant surfaces. Whereas the architecture of the cuticular structures and the associated functionalities have been well studied, detailed analyses concerning growth-induced changes in the morphology of cuticular structures are largely absent. Hong et al. [22

• of the ridges during cell expansion. From the second level to the third level, the ridge islands and the anticlinal fields undergo growth-induced expansion resulting in the observed morphological changes and alignment of ridges. Hong et al. [22] also reported that the densely arranged cuticular

The role of deep eutectic solvents and carrageenan in synthesizing biocompatible anisotropic metal nanoparticles

• Nabojit Das,
• Akash Kumar and
• Raja Gopal Rayavarapu

Beilstein J. Nanotechnol. 2021, 12, 924–938, doi:10.3762/bjnano.12.69

• stabilization of nanoparticles and determine morphological changes in a nanoparticle due to differential binding to crystal facets during the crystal growth phase of the nanoparticle during synthesis. However, there are reports on synthesizing nanomaterials without stabilizing agents but they were very

Silver nanoparticles nucleated in NaOH-treated halloysite: a potential antimicrobial material

• Yuri B. Matos,
• Rodrigo S. Romanus,
• Mattheus Torquato,
• Edgar H. de Souza,
• Rodrigo L. Villanova,
• Marlene Soares and
• Emilson R. Viana

Beilstein J. Nanotechnol. 2021, 12, 798–807, doi:10.3762/bjnano.12.63

• , 105, 230, and 505 °C. After that, TEM images were obtained to correlate morphological changes occurring during the synthesis with the thermodynamic data from DSC/TGA analysis. Finally, another 10 g of HNT-8 was loaded with AgNO3 and heated up to 700 °C, with visual inspections being performed at 40

A review of defect engineering, ion implantation, and nanofabrication using the helium ion microscope

• Frances I. Allen

Beilstein J. Nanotechnol. 2021, 12, 633–664, doi:10.3762/bjnano.12.52

On the stability of microwave-fabricated SERS substrates – chemical and morphological considerations

• Limin Wang,
• Aisha Adebola Womiloju,
• Christiane Höppener,
• Ulrich S. Schubert and
• Stephanie Hoeppener

Beilstein J. Nanotechnol. 2021, 12, 541–551, doi:10.3762/bjnano.12.44

• substrates treated with methanol, ethanol, or N,N-dimethylformamide (DMF) were comparable and showed overall good stability and did not show severe morphological changes or a strong decrease in their Raman activity. Toluene treatment resulted in a strong decrease in the Raman activity whereas dimethyl

• before and after treatment. Therefore, it can be used in an initial evaluation of the morphological changes observed on the substrates after their immersion into different solvents and buffer solutions in comparison to the respective reference samples. The projected particle size analysis of the

• microwave-fabricated SERS substrates (Figure 2a) indicates a reasonable reproducibility of the fabrication process (Supporting Information File 1, Figure S2) and can be used for the evaluation of the morphological changes, as exemplified by the samples which were treated for 1 h with water (Figure 2b). Both

A review on nanostructured silver as a basic ingredient in medicine: physicochemical parameters and characterization

• Gabriel M. Misirli,
• Kishore Sridharan and
• Shirley M. P. Abrantes

Beilstein J. Nanotechnol. 2021, 12, 440–461, doi:10.3762/bjnano.12.36

• blood tests, urinalysis, sputum induction, and magnetic resonance imaging of the chest and abdomen. After oral exposure, the silver content in the serum and urine was analyzed and no clinically abnormal changes were noted in the lungs, heart, or abdominal organs. Also, no morphological changes were

The nanomorphology of cell surfaces of adhered osteoblasts

• Christian Voelkner,
• Mirco Wendt,
• Regina Lange,
• Max Ulbrich,
• Martina Gruening,
• Susanne Staehlke,
• Barbara Nebe,
• Ingo Barke and
• Sylvia Speller

Beilstein J. Nanotechnol. 2021, 12, 242–256, doi:10.3762/bjnano.12.20

• ruffles moving beneath the pipette opening. Slightly higher rms amplitudes may also be due to different temperature because fixed cells are measured at room temperature, while live-cell imaging is carried out at 37 °C. Frequency response behavior Owing to the fact that morphological changes at the cell

Atomic layer deposited films of Al₂O₃ on fluorine-doped tin oxide electrodes: stability and barrier properties

• Hana Krýsová,
• Michael Neumann-Spallart,
• Hana Tarábková,
• Pavel Janda,
• Ladislav Kavan and
• Josef Krýsa

Beilstein J. Nanotechnol. 2021, 12, 24–34, doi:10.3762/bjnano.12.2

• on its surface (Figure S6, Supporting Information File 1), the surface of an FTO substrate covered by a thin conformal Al2O3 film does not show any significant morphological changes after the electrochemical treatment (Figure S7, Supporting Information File 1). The cathodic breakdown of FTO is also

Imaging and milling resolution of light ion beams from helium ion microscopy and FIBs driven by liquid metal alloy ion sources

• Nico Klingner,
• Gregor Hlawacek,
• Paul Mazarov,
• Wolfgang Pilz,
• Fabian Meyer and
• Lothar Bischoff

Beilstein J. Nanotechnol. 2020, 11, 1742–1749, doi:10.3762/bjnano.11.156

• thickness. Milling membranes removes their support from one side and dangling bonds can lead to morphological changes making milling tests difficult to interpret. In metal layers of a few nanometers thickness, sputter redeposition can take place, which is not taken into account in our static SRIM simulation

Electromigration-induced directional steps towards the formation of single atomic Ag contacts

• Atasi Chatterjee,
• Christoph Tegenkamp and
• Herbert Pfnür

Beilstein J. Nanotechnol. 2020, 11, 680–687, doi:10.3762/bjnano.11.55

• could not be identified visually nor be reproducibly generated. This contrasts with experiments where the smallest constriction was reduced by one order of magnitude down to about 15 nm using a focused ion beam (FIB), i.e., far below the average grain size in the Ag film, in which complex morphological

• changes were absent [28]. Thus, we have a well-defined reference system generated by EM. Therefore, it seems meaningful to obtain more details about the thinning process induced by EM in this system from the information contained within the experimental conduction histograms and their FTs. Furthermore

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

• Varsha Sharma and
• Anandhakumar Sundaramurthy

Beilstein J. Nanotechnol. 2020, 11, 508–532, doi:10.3762/bjnano.11.41

• applied to a variety of PEs. Multilayer capsules formed on such a variety of cores can reveal specific characteristics and are mostly studied using microscopy techniques such as scanning electron microscopy (SEM) and transmission electron microscopy (TEM) to observe their morphological changes. Moreover

• screening effect on multilayer bonds [44]. Similar morphological changes were observed when the temperature dependence of electrostatically bound capsules was studied with various PEs that are thermo-responsive [45]. Additionally, the effect of the dissolution of the core on the permeability of capsules was

• approached, the morphological changes in PVP/PMA capsules were seen with the decrease in multilayer thickness due to disruption of hydrogen bonds [50]. When the same was cross-linked by carbodiimide chemistry, the swelling was observed at higher pH, leading to the formation of highly swollen hydrogels. To

The effect of heat treatment on the morphology and mobility of Au nanoparticles

• Sven Oras,
• Sergei Vlassov,
• Simon Vigonski,
• Boris Polyakov,
• Mikk Antsov,
• Vahur Zadin,
• Rünno Lõhmus and
• Karine Mougin

Beilstein J. Nanotechnol. 2020, 11, 61–67, doi:10.3762/bjnano.11.6

• effect becomes clearly visible at 400 °C and increases further for higher temperatures (Table 1). To evaluate the morphological changes more quantitatively, we introduced a criterion based on the length of the facet: if the NP is smaller than 10% of its total visible perimeter, then it is classified as

• °C has been reported even for particles exceeding 100 nm in diameter [6]. To explain the rounding, it is probably more appropriate to consider the diffusion of surface atoms rather than complete melting. Another important factor for heat-induced morphological changes, overlooked by many other studies

Materials nanoarchitectonics at two-dimensional liquid interfaces

• Katsuhiko Ariga,
• Michio Matsumoto,
• Taizo Mori and
• Lok Kumar Shrestha

Beilstein J. Nanotechnol. 2019, 10, 1559–1587, doi:10.3762/bjnano.10.153

Effects of gold and PCL- or PLLA-coated silica nanoparticles on brain endothelial cells and the blood–brain barrier

• Aniela Bittner,
• Angélique D. Ducray,
• Hans Rudolf Widmer,
• Michael H. Stoffel and
• Meike Mevissen

Beilstein J. Nanotechnol. 2019, 10, 941–954, doi:10.3762/bjnano.10.95

• kidney cells. Si-NPs induced time- and concentration-dependent neuronal cell death by production of reactive oxygen species and reduction of glutathione levels [12]. Similarly, Si-NPs led to morphological changes, concentration-dependent membrane damage, decreased cell viability, increased apoptosis

In situ AFM visualization of Li–O₂ battery discharge products during redox cycling in an atmospherically controlled sample cell

• Kumar Virwani,
• Younes Ansari,
• Khanh Nguyen,
• Francisco José Alía Moreno-Ortiz,
• Jangwoo Kim,
• Maxwell J. Giammona,
• Ho-Cheol Kim and
• Young-Hye La

Beilstein J. Nanotechnol. 2019, 10, 930–940, doi:10.3762/bjnano.10.94

• and O2 reactions have been the subject of intense experimental and theoretical investigations [8][9][10][11][12][13][14][15][16][17]. Of particular relevance are investigations that shed light on the morphological changes that occur on the electrodes during the Li/O2 electrochemical reactions. Jung et

• charge transfer resistance, improves the kinetics of the reaction. Topographical observations using AFM AFM was used to monitor morphological changes on the glassy carbon cathode surface. The topography images in Figure 3 and Figure 4 each show one of the nine scanned regions at two different water

• cell discharge capacity at increased water concentration and the corresponding morphological changes on the glassy carbon cathode with this technique. For all measurements, the discharge was cut-off at 2 V vs Li and the recharge was cut-off at 4.6 V vs Li or 100% state-of-charge (SOC). Across different

An efficient electrode material for high performance solid-state hybrid supercapacitors based on a Cu/CuO/porous carbon nanofiber/TiO₂ hybrid composite

• Mamta Sham Lal,
• Thirugnanam Lavanya and
• Sundara Ramaprabhu

Beilstein J. Nanotechnol. 2019, 10, 781–793, doi:10.3762/bjnano.10.78

• route to establish novel composites based solid state symmetric hybrid supercapacitors. Our synthesized composite based electrode can be expected to become a strong competitor for energy storage in hybrid electric vehicles. Schematic illustration shows the morphological changes during different

Mechanism of silica–lysozyme composite formation unravelled by in situ fast SAXS

• Tomasz M. Stawski,
• Daniela B. van den Heuvel,
• Rogier Besselink,
• Dominique J. Tobler and
• Liane G. Benning

Beilstein J. Nanotechnol. 2019, 10, 182–197, doi:10.3762/bjnano.10.17

• units. The morphological changes of the composites further continue beyond 150 s. This is documented through the change in the form factor of the silica NPs that appear to grow in size, compared to the pre-mixed initial NPs. Although we cannot use our model to explain this last stage, we can speculate